Tuberous Sclerosis Complex — Foundation Learning Guide¶
For a reader with no background in this area. If you have watched the Foundations film series, this follows directly from it.
The one idea to hold¶
TSC1 and TSC2 act as a brake on mTOR, a growth pathway. Lose the brake and growth runs unchecked — which is why an mTOR inhibitor helps.
What this subject does with that idea¶
The whole factory applied to one disease: tuberous sclerosis complex, a genetic condition causing growths across multiple organs.
Five disease-specific agents compose the horizontal engines — variant curation, trajectory, therapeutics, phenotype mapping and TAND surveillance.
Decision support for a qualified clinician — never autonomous diagnosis or prescribing. Every output on this page is intended to inform a clinician's judgement, not replace it.
What it cannot do¶
Gene-therapy correction of TSC1/TSC2 is preclinical — an open design bench, not a cure today. Pediatric caution at full force. Decision support, never prescribing.
Stating the limit is not a disclaimer bolted on the end — it is how you tell a tool that helps from a tool that misleads.
Vocabulary you will meet¶
| Term | Plain meaning |
|---|---|
| Capability | One named thing the platform can do, registered in capabilities.json |
live / planned |
Whether a capability actually answers today, or is intended |
| Decision support | Output that informs a clinician; it never decides |
| LIVE / REPRESENTATIVE / BURST | Whether a demo ran now, was pre-computed, or ran on remote GPUs |
Try it¶
The demo for this subject is P1:
.venv/bin/python scripts/run_demo.py P1
If it reports BLOCKED, the message names exactly what is missing. That is intentional — a demo
that cannot run says so rather than showing you something canned.