Capability Brief — Technical Cut¶
The whole factory in one read: 8 engines · 8 intelligence agents · 1 disease program (TSC) on one platform. Every endpoint and status below is generated at build time from the capability registry — no hand-typed drift. For the human why, see the Mission Cut.
Illustrative architecture diagram — teal engines, indigo agents, ember TSC.
The roster¶
Engines¶
| Capability | Domain | Endpoint | Status |
|---|---|---|---|
| Cardiology Engine | clinical | localhost:8126 |
live |
| Clinical Imaging Engine | clinical | localhost:8525 |
live |
| Genomics Foundations Engine | genomics | localhost:5000 |
live |
| Large-Molecule / Structural Biology Engine | proteins | localhost:8579 |
live |
| Precision Intelligence Engine | clinical | localhost:5001 |
live |
| Precision Oncology Engine | clinical | localhost:8526 |
live |
| Single-Cell Analysis Engine | single_cell | localhost:8573 |
verified |
| Therapeutic Discovery Engine | small_molecules | localhost:8505 |
live |
Intelligence Agents¶
| Capability | Domain | Endpoint | Status |
|---|---|---|---|
| CAR-T Intelligence Agent | clinical | localhost:8521 |
live |
| Clinical Trial Intelligence Agent | clinical | localhost:8538 |
live |
| Neurology Intelligence Agent | clinical | localhost:8529 |
live |
| Pharmacogenomics Intelligence Agent | clinical | localhost:8507 |
live |
| Precision Autoimmune Intelligence Agent | clinical | localhost:8531 |
live |
| Precision Biomarker Intelligence Agent | clinical | localhost:8528 |
live |
| Rare Disease Intelligence Agent | clinical | localhost:8544 |
live |
| Single-Cell Intelligence Agent | clinical | localhost:8540 |
live |
Models & NIMs¶
| Capability | Domain | Endpoint | Status |
|---|---|---|---|
| ADMET / Toxicity Prediction | small_molecules | localhost:8572 |
verified |
| Chai-1 Complex Structure Prediction | proteins | — |
planned |
| Chai-2 De Novo Antibody / Binder Design | proteins | — |
gated |
| DiffDock Docking | small_molecules | localhost:8002 |
live |
| ESM-2 LoRA Fine-Tuning | proteins | library |
planned |
| ESMFold Structure Prediction | proteins | localhost:8570 |
verified |
| GenMol Generator | small_molecules | — |
planned |
| MolMIM Generator | small_molecules | localhost:8001 |
live |
| Molecule Generator (diversity) | small_molecules | localhost:8574 |
verified |
| Protein Developability + Design | proteins | localhost:8576 |
planned |
| Protein Sequence Search | proteins | localhost:8571 |
verified |
| ProteinMPNN Inverse Folding | proteins | localhost:8578 |
verified |
| pMHC-I Immunogenicity (MHCflurry) | proteins | localhost:8577 |
planned |
Platform Services & Pipeline Stages¶
| Capability | Domain | Endpoint | Status |
|---|---|---|---|
| ACMG SF Secondary Findings | genomics | library |
verified |
| AI Workflow Composer | platform | — |
live |
| Assistant Tool-Surface (MCP) | platform | — |
live |
| Event Bus | platform | library |
live |
| GWAS Association Testing | genomics | library |
live |
| Local MLOps | platform | library |
live |
| Observability | platform | localhost:3000 |
live |
| Queryable Variant Store | genomics | localhost:8575 |
verified |
| Reproducibility Manifest | platform | library |
verified |
| VAF / Somatic-Mosaicism Flag | genomics | localhost:8575 |
planned |
| Vector Database | platform | localhost:19530 |
live |
| Verify Gate | platform | library |
live |
Flagship disease program¶
Tuberous Sclerosis Complex composes the horizontals for one child in one governed afternoon — TSC1/TSC2 → mTORC1 → everolimus. Gene therapy is preclinical; everolimus is real and approved.
Honesty¶
All clinical output is decision support for a qualified clinician, never autonomous diagnosis. See the live Capability Maturity Matrix and the Honesty Ledger. A live capability is never mock-served.
Generated from the registry
This page's roster, endpoints, and statuses are generated from lib/hcls_common/capabilities.json at build time — the site cannot claim ahead of the code.